Support for Nitric Oxide Production and Vascular Health Dietary Supplement Non-GMO Optimal heart health depends on many factors, including proper endothelial function. Even with cholesterol/glucose levels in the healthy range, aging individuals need to maintain youthful integrity of their endothelium—the thin layer of cells lining the interior of the entire circulatory system. Cordiart (extract from sweet orange peels) activates endothelial production of nitric oxide, which signals the smooth muscles to relax, inducing vasodilation to support healthy circulation. In clinical research, 500 mg of Cordiart alone produced an 18% improvement in flow mediated dilation, a direct marker of endothelial function. Cordiart also inhibited the pro-inflammatory factors C-reactive protein and serum amyloid A that interrupt healthy nitric oxide production.