Gluten Free Dietary Supplement Women's Health Foundational Optimal balance of B vitamins with extra B6 for brain and nerve health and PMS discomfort. B-Complex #6 includes essential B vitamins. Its extra B6 is important for neurotransmitter synthesis, which is essential for stress and mood support. It can also help modulate fluid retention. Most B vitamins, with the exception of vitamin B12, are not stored in the body; consequently, they must be acquired daily from the diet in order to maintain optimal health. Thorne's B-Complex #6 contains an optimal balance of essential B vitamins with extra vitamin B6. B-Complex #6 contains thiamine (vitamin B1), riboflavin and riboflavin 5'-phosphate (vitamin B2), niacinamide (vitamin B3), pantothenic acid (vitamin B5), pyridoxine and pyridoxal 5'-phospate (vitamin B6), methylcobalamin (vitamin B12), methyl-folate (5-MTHF), and biotin. Although each B vitamin is chemically distinct, they often work together in various biochemical functions throughout the body – from cellular energy production, to healthy red-blood-cell formation, to healthy neurological function. B-Complex #6 offer both pyridoxine and active pyridoxal 5'-phosphate to support brain function through neurotransmitter synthesis and neurological function through the formation of the myelin sheath surrounding nerve cells. B6 can also help relieve the symptom of fluid retention and support a good mood in individuals with premenstrual syndrome (PMS). Supplementing with active B vitamins is important for everyone, and especially for individuals whose livers may not be able to convert the non-active B vitamin forms to their active forms because of compromised liver function, poorly functioning enzymes, digestive disturbances, or age. Pyridoxine (vitamin B6) and its bioactive form, pyridoxal 5'-phosphate (P5P), are essential for such processes as amino acid metabolism, neurotransmitter synthesis, and glycogen (storage sugar) breakdown. Pyridoxine and P5P are also involved in heme synthesis (necessary for hemoglobin), conversion of tryptophan to niacin, and the proper metabolism of fatty acids. Thorne's B-Complex #6 supplies 200 mg of pyridoxine HCl, 10 mg pyridoxal 5'-phosphate, and the bioactive forms of other B vitamins in each capsule to provide an optimally bioavailable B complex.