S-Adenosyl-Methionine Supports Joints and Emotional Well-Being Dietary Supplement SAMe has multiple mechanisms of action that are used throughout the body Brain and Mood SAMe boosts brain cell methylation and facilitates youthful DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters such as norepinephrine, dopamine, and seratonin and may account for SAMe's mood-elevating properties. SAMe also helps maintain acetylcholine levels which are necessary for cognitive function. Liver and Detox In order to perform its detoxification role, the liver continually performs large numbers of complex enzymatic reactions. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant. Joint SAMe may help to ease inflammation and can support healthy joint mobility and function without side effects.