The Safe, Pure Butterbur Relaxes Blood Vessels in the Head Dietary Supplement Enzymatic Therapy’s Petadolex Pro-Active supplement contains pure butterbur extract to support healthy blood vessel tone in the head, as well as normal blood flow in the brain. The patented method of extraction for Petadolex Pro-Active ensures the valuable petasites compounds are captured, while leaving out toxic levels of inherent compounds such as pyrrolizidine alkaloids. This product is tested for pyrrolizidine alkaloids to guarantee safety, made possible by using this patented process (U.S. Patent #6,551,626). For soothing comfort that improves with continued use, trust Petadolex Pro-Active for your entire family, as it is effective in both adults and children! Petadolex Pro-Active supports healthy blood vessel relaxation in the brain. Blood vessel tone is influenced, in part, through neuralgic, vascular, and chemical factors. Butterbur (Petasites hybridus) contains several compounds with bioactive properties. Two of these compounds, petasin and isopetasin support healthy blood vessel tone and circulation. Petasin additionally provides nutritional support for cellular activity associated with the functioning of healthy blood vessel walls.