Nervous System Support Supports Emotional Well-Being Supports Joint Health Enteric Coated A Dietary Supplement Vegetarian/Vegan Amino Acids Family Owned Since 1968 GMP Quality Assured SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to alleviate transient minor aches and pains resulting from overexertion or strain. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in mood support. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.